The Hilarious All-Star Cast Of St. Denis Medical: Where You’ve Seen Them Before And What To Expect In Season 2
The NBC workplace comedy St. Denis Medical has quickly become a fan-favorite, delivering a fresh, chaotic, and hilarious take on the hospital mockumentary genre. Co-created by Justin Spitzer, the mastermind behind Superstore and The Office, the show’s success hinges entirely on its stellar ensemble cast, a mix of veteran comedic geniuses and breakout stars. As of December 2025, fans are eagerly anticipating the next round of medical mayhem, with the show officially renewed and its second season premiere date locked in for late 2025. This article dives deep into the talented actors who bring the underfunded, understaffed St. Denis hospital to life, detailing their characters and their most famous roles before they stepped into the scrubs.
The series, which first premiered in November 2024, follows a dedicated but often overwhelmed staff navigating the daily absurdities of a low-resource Oregon hospital. From a controlling head nurse to a self-aggrandizing trauma surgeon, the chemistry among the cast is undeniable, making it one of the most talked-about new sitcoms on television. Get ready to meet the faces behind the funniest doctors and nurses on TV today.
Meet the Core Cast and Their Iconic Roles
The main ensemble cast of St. Denis Medical is a powerhouse of comedic talent, many of whom are reuniting with creator Justin Spitzer or have a long history in the mockumentary and sitcom world. Here is a complete breakdown of the main actors, their characters, and their impressive careers.
Wendi McLendon-Covey as Joyce
- Character Role: Joyce, the hospital's CEO who tries to maintain a facade of competence and control despite the constant chaos and lack of funding. She is the driving, often misguided, force of the hospital’s administration.
- Previous Iconic Roles:
- Beverly Goldberg in The Goldbergs: Her long-running role as the overbearing, yet loving, 'smother' matriarch of the Goldberg family.
- Deputy Clementine Johnson in Reno 911!: A fan-favorite, unhinged deputy in the classic mockumentary series.
- Rita in Bridesmaids: Her breakout performance in the critically acclaimed and commercially successful 2011 comedy film.
David Alan Grier as Dr. Ron
- Character Role: Dr. Ron, a seasoned, witty, and slightly jaded emergency room doctor. He is the voice of experience and often the most pragmatic member of the staff, though not without his own quirks.
- Previous Iconic Roles:
- Various Characters in In Living Color: A foundational member of the groundbreaking sketch comedy series, showcasing his versatility and comedic timing.
- James "Lightning" McQueen in Race: His Tony Award-nominated performance on Broadway.
- The Wiz/Uncle Henry in The Wiz Live!: Demonstrating his talents across television, film, and theater.
Allison Tolman as Alex
- Character Role: Alex, the controlling, conscience-driven Registered Nurse and Head Nurse who attempts to keep the under-control team afloat while struggling with her own work-life balance issues.
- Previous Iconic Roles:
- Deputy Molly Solverson in Fargo (Season 1): Her breakout, Emmy and Golden Globe-nominated role that earned her critical acclaim.
- Jo Evans in Emergence: A leading role in the mystery-thriller series.
- Mary Pat in Good Girls: A memorable recurring role in the crime comedy-drama.
Josh Lawson as Dr. Bruce Schweitz
- Character Role: Dr. Bruce Schweitz, a zany, cocky, and self-aggrandizing trauma surgeon who loves the spotlight and often prioritizes personal fame over patient care.
- Previous Iconic Roles:
- Kano in Mortal Kombat (2021): Known for his darkly comedic and memorable portrayal of the iconic video game villain.
- Doug Guggenheim in House of Lies: A major supporting role in the Showtime comedy series.
- Various Roles in Australian TV and Film: The Australian actor has a robust career in his home country.
Mekki Leeper as Matt
- Character Role: Matt, one of the younger, more awkward members of the staff, whose earnest efforts often lead to comical mishaps.
- Previous Iconic Roles:
- Noah Price in Jury Duty: Starred in and was an Emmy-nominated writer for the viral, Peabody Award-winning mockumentary series.
- Eric in The Sex Lives of College Girls: A recurring supporting role in the Mindy Kaling-created comedy.
- Stand-up Comedian: A successful writer and stand-up comic, bringing a unique, dry humor to the show.
Kaliko Kauahi as Nurse Val
- Character Role: Nurse Val, the nurse administrator who often serves as the hospital’s only grown-up, trying to bring a sense of order to the chaos.
- Previous Iconic Roles:
- Sandra Kaluiokalani in Superstore: Best known for her long-running, beloved role as the oddball, quiet, but fiercely loyal Cloud 9 employee, reuniting her with creator Justin Spitzer.
- Supporting Roles in Parks and Recreation and Modern Family: Further cementing her status as a reliable comedic supporting player.
Kahyun Kim as Serena
- Character Role: Serena, a nurse whose character is often involved in the show's more absurdist and high-energy storylines, forming a great comedic duo with Mekki Leeper’s Matt.
- Previous Iconic Roles:
- Brenda in Cocaine Bear: Appeared in the 2023 dark comedy film.
- Kai in American Gods: Had a series regular role in the Starz fantasy drama.
- Guest Roles in Shameless and Timeless: Showcasing her range across different genres.
The Mockumentary Magic: Why This Ensemble Works
The key to St. Denis Medical's success lies in its adherence to the mockumentary format, a style perfected by many of the cast members in their previous work, such as Wendi McLendon-Covey in Reno 911! and Mekki Leeper in Jury Duty.
The show employs the signature single-camera, direct-to-camera interview style, allowing the actors to break the fourth wall and offer hilarious, often self-serving, commentary on the hospital’s daily operations. This technique highlights the individual comedic strengths of the ensemble, from David Alan Grier's subtle, jaded one-liners to Josh Lawson’s over-the-top physical comedy as Dr. Bruce.
The casting, spearheaded by creator Justin Spitzer, deliberately brought together actors with a proven track record in this niche of comedy. The reunion of Kaliko Kauahi with Spitzer, after their successful collaboration on Superstore, was a clear signal to fans of what kind of workplace humor to expect: warm, character-driven, and incredibly sharp.
What’s Next? St. Denis Medical Season 2 Updates
The most current and exciting news for fans is the confirmed return of the entire main cast for a second season. The show’s renewal was announced earlier in the year, cementing its place as a new staple in NBC's comedy lineup.
The highly anticipated St. Denis Medical Season 2 is scheduled to premiere on Monday, November 3, 2025, with a special two-episode launch event on NBC and streaming on Peacock.
Season 2 is expected to delve deeper into the personal lives of the staff while maintaining the high-stakes, low-budget atmosphere of the St. Denis hospital. Fans are eager to see the ongoing dynamic between Head Nurse Alex (Allison Tolman) and CEO Joyce (Wendi McLendon-Covey), whose conflicting management styles provide much of the show’s central tension. The next season is also rumored to feature exciting guest stars, including personalities like Ariana Madix and Kristen Schaal, promising even more outrageous patient and staff interactions.
With its strong foundation in the mockumentary format and an all-star cast that knows exactly how to play the genre, St. Denis Medical is set to deliver another dose of necessary, side-splitting workplace comedy in its second season. The combination of established legends and rising stars ensures that the chaotic, yet lovable, hospital staff will continue to entertain audiences for the foreseeable future. Get ready to tune in this November 2025.
Detail Author:
- Name : Oscar Gusikowski
- Username : pfisher
- Email : xfunk@yahoo.com
- Birthdate : 1972-11-14
- Address : 1090 Mills Harbors New Rita, NJ 29082-9253
- Phone : (740) 301-5538
- Company : Vandervort, Bartoletti and Gerlach
- Job : Industrial Safety Engineer
- Bio : Excepturi accusantium ea odit quae. Vel qui quasi sit fuga recusandae. Veniam aut omnis aut est odit aut autem est. Consequuntur dignissimos mollitia odio in perferendis harum temporibus.
Socials
facebook:
- url : https://facebook.com/tconsidine
- username : tconsidine
- bio : Repellat earum sit quod ullam distinctio explicabo ullam voluptas.
- followers : 4807
- following : 2842
instagram:
- url : https://instagram.com/teresa_id
- username : teresa_id
- bio : Qui ut eum sit molestiae. Excepturi quo quidem similique sapiente non. Esse vero quod enim et vel.
- followers : 1311
- following : 388
linkedin:
- url : https://linkedin.com/in/considine1978
- username : considine1978
- bio : Eum est atque minima id fuga est ea.
- followers : 5954
- following : 2285
